Stephen C. Bondy, PhD


University of California, Irvine
Room 320, Med Surge II
Mail Code: 1825
Irvine, CA 92697


Education & Training:
M.A., University of Cambridge, England
Ph.D., University of Birmingham, England

Teaching: Environmental Toxicology
Pharmacology and Toxicology

Research Interests: Research focuses on the role of environmental factors in the initiation or potentiation of neurodegenerative diseases. In this context the emphasis is on the contribution of inflammatory events to neural aging. The potential slowing of brain aging by antioxidants and antiinflammatory agents such as melatonin, is also under investigation. Such retardation could reduce the incidence of specific age-related neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

Recent Publications:

Zhou J, Yang F, Zhou L, Wang JG, Wen P, Luo H, Li W, Song Z, Sharman EH, Bondy SC. Dietary melatonin attenuates age-related changes in morphology and in levels of key proteins in globus pallidus of mouse brain. Brain Res 1546:1-8, 2014.

Campbell A, Sharman E, Bondy SC. Age-related differences in the response of the brain to dietary melatonin. Age 36(1):49-55, 2014.

Wang JG, Bondy SC, Zhou L, Yang FZ, Ding ZG, Hu Y, Tian Y, Wen PY, Luo H, Wang F, Li WW, Zhou J. Protective effect of Tanshinone IIA against infarct size and increased HMGB1, NFκB, GFAP and apoptosis consequent to transient middle cerebral artery occlusion. Neurochem Res 39(2):295-304, 2014.

Bondy SC. Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration. Toxicology 315:1-7, 2014.

Prasad KN, Bondy SC. Evaluation of role of oxidative stress on aging in Caenorhabditis elegans: a brief review. Curr Aging Sci 6(3):215-9, 2013.

Jun Z, Li Z, Fang W, Fengzhen Y, Puyuan W, Wenwen L, Zhi S, Bondy SC. Melatonin decreases levels of S100β and NFΚB, increases levels of synaptophysin in a rat model of Alzheimer's disease. Curr Aging Sci 6(2):142-9, 2013.

Lung S, Li H, Bondy SC, Campbell A. Low concentrations of copper in drinking water increase AP-1 binding in the brain. Toxicol Ind Health. 2013 May 29 (Epub ahead of print), 2013.

Bondy SC. Nanoparticles and colloids as contributing factors in
neurodegenerative disease. Int J Environ Res Public Health 8(6):2200-11, 2011.

Zhou J, Zhou L, Hou D, Tang J, Sun J, Bondy SC. Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease. Brain Res 1388:141-7, 2011.

Sharman EH, Sharman KG, Bondy SC. Extended exposure to dietary melatonin reduces tumor number and size in aged male mice. Exp Gerontol 46(1):18-22, 2011.

Bondy, S. C. The neurotoxicity of environmental aluminum is still an issue. Neurotoxicology 31: 575-581, 2010.

Ali, S. F. and Bondy, S. C. Red wine but not ethanol at low doses can protect against the neurotoxicity of methamphetamine. Brain Res. 1346:247-250, 2010.

Bondy, S. C., Li, H., Zhou, J., Wu, M., Bailey, J. A. and Lahiri, D. K. Melatonin alters age-related changes in transcription factors and kinase activation. Neurochem. Res. 35: 2035-2042, 2010.

Lahiri, D. K., Ghosh, C., Rogers, J. T., Bondy, S. C., and Greig, N. H. Role of nitric oxide in neurodegeneration and vulnerability of neuronal cells to nitric oxide metabolites and reactive oxygen species. In: Oxidative Stress in Basic Research and Clinical Practice : Aging and Age-Related Disorders. (eds: Bondy, S. C. and Maiese, K.), Humana Press, Totowa NJ, pp. 399-415, 2010.

Bondy, S. C. and Sharman, E. H. Melatonin, oxidative stress and the aging brain. In: Oxidative Stress in Basic Research and Clinical Practice : Aging and Age-Related Disorders (eds: Bondy, S. C. and Maiese, K.), Humana Press, Totowa NJ, pp. 339-357, 2010.

Bondy, S. C. and Maiese, K. (eds.): Oxidative Stress and its Relation to Aging. Volume in series: Oxidative Stress in Applied Basic Research and Clinical Practice. 2010.