Michael T. Kleinman
Adjunct Professor


University of California, Irvine
FRF 100
Mail Code: 1825
Irvine, CA 92697


Education & Training: M.S., Biochemistry, Polytechnic Institute of Brooklyn
Ph.D., Environmental Health Sciences, New York University

Teaching: Environmental Toxicology

Research Interests: Environmental pollutants represent important potential causes of preventable neurological, cardiological and pulmonary diseases. The research in my laboratory uses immunological and molecular methods to examine the mechanisms by which toxic agents affect the lung and heart. Current studies include the effects of ambient particles on blood pressure and heart rate in sensitive animal models. Other studies examine the link between asthma and environmental exposures to ambient particles near real-world pollutant sources, such such as freeways in Los Angeles.

Recent Publications:

Kim YD, Lantz-McPeak SM, Ali SF, Kleinman MT, Choi YS, Kim H. 2014. Effects of ultrafine diesel exhaust particles on oxidative stress generation and dopamine metabolism in PC-12 cells. Environmental Toxicology and Pharmacology 37(3):954-9.

Ljubimova JY, Kleinman MT, Karabalin NM, Inoue S, Konda B, Gangalum P, Markman JL, Ljubimov AV, Black KL. 2013. Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: comparison with human brain tumors. Experimental and Toxicologic Pathology 65(7-8):1063-71.

Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen JC, Cory-Slechta DA, Costa D, Diaz-Sanchez D, Dorman DC, Gold DR, Gray K, Jeng HA, Kaufman JD, Kleinman MT, Kirshner A, Lawler C, Miller DS, Nadadur SS, Ritz B, Semmens EO, Tonelli LH, Veronesi B, Wright RO, Wright RJ. The outdoor air pollution and brain health workshop. 2012. Neurotoxicology 33(5):972-84.

Li, N., Harkema, J. R., Lewandowski, R. P., Wang, M., Bramble, L. A., Gookin, G. R., Ning, Z., Kleinman, M. T., Sioutas, C. and Nel, A. E. 2010. Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares. Am J Physiol Lung Cell Mol Physiol 299: L374-383.

Richards NK, Wingen LM, Callahan KM, Nishino N, Kleinman MT, Tobias DJ, Finlayson-Pitts BJ. 2011. Nitrate ion photolysis in thin water films in the presence of bromide ions. Journal of Physical Chemistry 115(23):5810-21.

Wu J, Edwards R, He XE, Liu Z, Kleinman M. 2010. Spatial analysis of bioavailable soil lead concentrations in Los Angeles, California. Environ Res 110(4): 309-317.

Simkhovich BZ, Kleinman MT, Kloner RA. 2009. Particulate air pollution and coronary heart disease. Current Opinion in Cardiology 24(6): 604-609.

Campbell A, Araujo JA, Li HH, Sioutas C, Kleinman M. 2009. Particulate Matter Induced Enhancement of Inflammatory Markers in the Brains of Apolipoprotein E Knockout Mice. Journal of Nanoscience and Nanotechnology 9(8): 5099-5104.

Kleinman MT, Araujo J, Nel A, Sioutas C, Campbell A, Cong PQ, Li A, Bondy SC, Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways, Toxicol Lett 178, 127-130, 2008.

Simkhovich BZ, Kleinman, MT, Kloner RA, Air pollution and cardiovascular injury: epidemiology, toxicology and mechanisms, J. Amer. Coll. Cardiol. 52:719-726, 2008.

Kleinman, MT, Sioutas, C, Froines, J, Fanning, E, Hamade, A, Meacher, D and Oldham, M., Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice: relevance of particle composition and size, Inhal. Toxicol., 19 Suppl 1: 117-126, 2007.

Kleinman, M.T., Hyde, D., Bufalino, C., Basbaum, C., Bhalla, D.K. and Mautz, W.J Toxicity of Chemical Components of Fine Particles Inhaled by Aged Rats: Effects of Concentration. J. Air and Waste Management Assoc.53: 1080-1087, 2003.

Kleinman, M.T., Chang, M, Sioutas, C. and Cassee, F. Fine and coarse ambient particles suppress macrophage function. Toxicol. Letters 151-158, 2003.

Hall JV; Winer AM; Kleinman MT; Lurmann FW; Brajer V; Colome SD. Valuing the health benefits of clean air. Science, 1992 Feb 14, 255(5046):812-7.

Kleinman, M.T., Chang, M, Sioutas, C. and Cassee, F. 2002, Fine and coarse ambient particles suppress macrophage function. Toxicol. Letters 3:197-208.

Kleinman, M.T., Bufalino, C, Rasmussen, R. Hyde, D., Bhalla, D.K. and Mautz, W.J. Toxicity of chemical components of ambient fine particulate matter (PM2.5) inhaled by aged rats. J. Appl. Toxicol. 357-364, 2000.

Kleinman, M.T. Health Effects of Carbon Monoxide, in Environmental Toxicants, 2nd Edition M. Lippmann, ed. Van Nostrand Reinhold, publishers, New York, Jan. 2000.

Solomon, C., Christian, D. L., Chen, L. L., Welch, B. S., Kleinman, M. T., Dunham, E., Erle, D. J. and Balmes, J. R. Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets. European Respiratory Journal 15:922-928, 2000.

Bondy, S.C., Ali, S.F. and Kleinman, M.T. Exposure of mice to tobacco smoke attenuates the toxic effects of methamphetamine on dopamine systems. Toxicol. Letters 118:43-46, 2000.

Chen Y, Douglass T, Jeffes EW, Xu Q, Williams CC, Arpajirakul N, Delgado C, Kleinman M, Sanchez R, Dan Q, Kim RC, Wepsic HT, Jadus MR. Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a "paraptosis"-induced pathway that promotes systemic immunity against intracranial T9 gliomas. Blood 100:1373-1380, 2002.

Jenkins, B.M., Mehlschau, J.J., Williams, R.B., Solomon, C., Balmes, J., Kleinman, M. And Smith, J. Rice Straw Smoke Generation System for Controlled Human Inhalation Exposures. Aerosol Sci. And Technol. 37: 437-454, 2003.

Opperhuizen, A., Buringh, E. And Kleinman, M.T. Compliance with PM standards in the European Union: A Netherlands case study. Environ. Management 53: 24-32, 2003.