Michael T. Kleinman, in collaboration with the Huntington Medical Research Institute, was awarded a new grant from the UC Tobacco-Related Disease Research Program (TRDRP) to study whether smoking impairs recovery from a heart attack.
Dr. Kleinman was also appointed to the Air and Energy Subcommittee of the USEPA Board of Scientific Counselors (BOSC). The BOSC provides advice, information, and recommendations to EPA’s Office of Research and Development (ORD) on technical and management issues of its research programs.
Recent Faculty Publications
Choi B. Job strain, long work hours, and suicidal ideation in US workers: a longitudinal study. International Archives of Occupational and Environmental Health (2018, in press). doi.org/10.1007/s00420-018-1330-7. This is the first longitudinal study that clearly demonstrated significantly positive associations of job strain (a combination of low job control and high job demands) and long work hours with moderate/severe suicidal ideation in a working population after controlling for other chronic work stressors and also family history of suicide. Increasing job control and ensuring optimal level of work demands, including 40 h or less of work per week may be an important strategy for the prevention of suicide in US working populations.
Lim J, Luderer U. 2018. Glutathione Deficiency Sensitizes Cultured Embryonic Mouse Ovaries to Benzo[a]pyrene-Induced Germ Cell Apoptosis. Toxicology and Applied Pharmacology. 352: 38-45. doi:10.1016/j.taap.2018.05.024 Benzo[a]pyrene is a common environmental pollutant found in grilled foods, air pollution, and tobacco smoke. This research shows that decreased ability to synthesize the antioxidant glutathione increases the sensitivity of the developing ovary to destruction of germ cells by exposure to benzo[a]pyrene.
Ljubimova JY, Braubach O, Patil R, Chiechi A, Tang J, Galstyan A, Kleinman MT et al. 2018. Coarse particulate matter (pm2.5-10) in los angeles basin air induces expression of inflammation and cancer biomarkers in rat brains. Sci Rep 8:5708. doi: 10.1038/s41598-018-23885-3
Mishra B, Lawson GW, Ripperdan R, Ortiz L, Luderer U. 2018. Charged Iron Particles Are Potent Inducers of Epithelial Ovarian Tumors. Radiation Research. 2018 May 21. doi:10.1667/RR15028.1. [Epub ahead of print]. This paper shows that a relatively low dose of charged iron particles, which are components of galactic cosmic rays, cause ovarian tumors later in life in mice. This raises concern that ovarian tumors may be a possible late consequence of travel in deep space.
COEH Research Seminars
We hold monthly COEH Research Seminars during the academic year. Information on these events as well as our weekly Environmental Health Sciences seminars may be found here. If you would like to be added to our seminar mailing list, please click here or contact us at 949-824-8641.