Abstract
Fine particulate matter (PM2.5) exposure accelerates atherosclerosis and contains known ovotoxic chemicals. However, effects of exposure to PM2.5 on the finite ovarian follicle pool have hardly been investigated, nor have interactions between ovarian and cardiovascular effects. We hypothesized that subchronic inhalation exposure to human-relevant concentrations of PM2.5 results in destruction of ovarian follicles via apoptosis induction, as well as accelerated recruitment of primordial follicles into the growing pool. Further, we hypothesized that destruction of ovarian follicles enhances the adverse cardiovascular effects of PM2.5 in females.
Authors
Ulrike Luderer, Jinhwan Lim, Laura Ortiz, Johnny D. Nguyen, Joyce H. Shin, Barrett D. Allen, Lisa S. Liao, Kelli Malott, Veronique Perraud, Lisa M. Wingen, Rebecca J. Arechavala, Bishop Bliss, David A. Herman & Michael T. Kleinman
